Thomas Thorne
Curious if you can get high on adrafinil? If so, you have come to the perfect place. The forums are full of misconceptions about the so-called “high adrafinil”And in this guide we will try to put an end to the discussion.
Adrafinil is increasingly popular among researchers as a surveillance-promoting drug due to its ease of availability and low-risk profile. Below, we'll go over the benefits, side effects, and safety of adrafinil, and how it compares to modafinil.
PS order your Adrafinil today!
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What is adrafinil?
Adrafinil is an oral “wake-promoting” drug also known as “eugeroic.” It was discovered in France in 1974 and developed by Louis Lafon Laboratories before being released under the product name "Olmifon" in 1985.1].
The main use of Olmifon was to treat elderly patients who had difficulty staying alert during the day. It was also used to treat patients with narcolepsy, a rare disease that causes extreme sleepiness during waking hours.
Adrafinil is essentially a "prodrug" of modafinil, meaning that adrafinil is metabolized (converted in the liver) to the active metabolite modafinil, as well as modafinil acid and modafinil sulfone. Adrafinil and modafinil are structurally very similar, the only difference is that adrafinil contains a terminal hydroxyl amide group while modafinil does not.2].
When Lafon introduced modafinil in 1994 under the brand name “Modiodal,” Olmifon quickly fell out of use. Lafon was acquired by Cephalon in the early 2000s, and manufacturing of Olmifon continued in France until 2011, after which authorities French doctors withdrew their approval.
Today, many pharmaceutical companies produce generic versions of adrafinil and it is widely sold as "reference material" for researchers in most countries.
Adrafinil benefits
The main benefit of Adrafinil is that it increases alertness in elderly patients and helps treat patients with narcolepsy. To date, there have been no widespread human clinical trials on the use of adrafinil in other age groups or to treat other ailments. However, research indicates that adrafinil offers several additional benefits beyond promoting wakefulness and alertness.
Cognitive neuroenhancement
Outside of medical research, the main demand for adrafinil comes from those seeking to investigate the neurological enhancement potential of adrafinil. A 2000 study by Siwak CT et al found that adrafinil caused a "long-lasting increase in high-frequency electroencephalographic activity" in dogs, suggesting an increase in "performance motivation" [3].While these findings have not been replicated in human trials, anecdotal evidence suggests that adrafinil is gaining notoriety as a “smart drug” or “nootropic” among people who believe it offers similar effects in humans.
While the evidence on adrafinil is scarce, much research has been done on its active metabolite, modafinil, which has been found to act as a powerful nootropic. Studies have shown that modafinil can improve mood, memory, and concentration in healthy subjects who are not sleep deprived.4], and that students and professionals widely take it as the so-called “smart drug.” As modafinil is a prescription medication in most countries, researchers interested in neurological enhancement are increasingly turning their attention to adrafinil, which is not subject to the same restrictions.
Improved athletic performance
Another potential benefit of adrafinil is that it may improve athletic performance. In 2004, the World Anti-Doping Organization (WADA) banned both adrafinil and modafinil in sports. Anecdotally, this indicates that the benefits offered by these drugs are beneficial for sports and help improve sports performance.5].
While the mechanism of action of adrafinil is not fully understood, a 1985 study by Milhaud CL et al indicated that it has a positive impact on animal locomotion. The study found that adrafinil had a significant impact on the nocturnal activity of rhesus monkeys. At doses of 60 mg/kg, adrafinil doubled the animal's nocturnal activity, while doses of up to 120 mg/kg increased its activity fourfold.6].
A cost-effective alternative to modafinil?
Although adrafinil has not been studied or approved as a substitute for modafinil, anecdotal evidence suggests that many people use it as such, especially in cases where brand-name modafinil is unavailable or unaffordable.
Because adrafinil is sold in most countries as a “reference material,” it is more widely available, albeit with some restrictions, compared to modafinil. For self-funded research, purchasing adrafinil is cheaper and this makes it attractive to researchers working in experimental settings.
Despite the limited scientific studies on the uses of adrafinil, there are some documented side effects that you should be aware of and which we will discuss in the next section.
Side effects and safety of adrafinil
Although modafinil has been studied much more than adrafinil, both drugs are structurally very similar and therefore cause similar side effects. The side effects of modafinil are well researched and understood [7]. They include:
- Headaches,
- Nausea,
- Diarrhea,
- Dryness of the throat, nose and
- mouth,
- Insomnia,
- Anxiety,
- nervousness and
- Dependence (if taken in high doses for long periods).
According to the product insert included in “Olmifon” packages, clinical tests have reported that adrafinil can cause skin irritations, stomach pains, internal tension and headaches. However, the literature makes it clear that adrafinil has not been tested in non-elderly test subjects.
Independent research has linked adrafinil to two specific side effects not typically associated with modafinil use: elevated liver enzyme values and orofacial dyskinesia, both of which we discuss below.
Adrafinil “high” | What you should know
If you are curious about what adrafinil feels like when you take it, this is the section for you.
Contrary to what you may have read or heard, adrafinil does not get you high. What we do know is that it is a non-amphetamine drug that promotes wakefulness and helps increase concentration, attention and motivation in elderly patients.
The package information for "Olmifon" (trade name adrafinil) suggests that patients follow their doctor's instructions and take 2 to 4 tablets per day, giving a range of 600 to 1200 mg. Even at these seemingly high doses, adrafinil does not cause a “high” sensation.
Search results for “adrafinil high” on Reddit indicate that most users do not feel any effects from adrafinil; it simply helps them stay alert without feeling tired [11]. This anecdotal evidence suggests that there is no correlation between adrafinil dosage and whether a test subject or patient feels "high."
Among subjects receiving adrafinil to improve neurocognition, the consensus is that 300 mg of adrafinil is approximately equivalent to 100 mg of modafinil. Since the typical dose of modafinil is 100 to 200 mg, the equivalent dose of adrafinil would be between 300 and 600 mg.
A very low daily dose of adrafinil would be 100 mg, while the most common dose is 200 to 300 mg. Even at strong doses of 600 mg (equivalent to 200 mg of modafinil), adrafinil does not create a "high" feeling.
Adrafinil typically takes 1 to 2 hours to take effect and lasts 6 to 12 hours. Its effects tend to peak between 4 and 6 hours after administration. However, this period is not accompanied by any feeling of “euphoria”.
Adrafinil versus modafinil
Adrafinil is a prodrug of modafinil and there is research indicating that the two medications can be used interchangeably by those seeking pharmaceutical cognitive enhancement, such as longer concentration and increased alertness. However, there are significant differences between these two substances. These are the main things you need to know.
Adrafinil is cheaper
Researchers interested in studying eugeroic may be interested in the low price of adrafinil compared to modafinil. Our preferred supplier sells 30 mL vials of adrafinil solution for $19.99 and applies discounts for bulk purchases.
Modafinil is more powerful than adrafinil
Clinical trials have shown that modafinil is more potent than adrafinil and has a stronger impact on wakefulness. While the recommended dosage for Olmifon is 600 to 1200 mg/day, the most common indication for modafinil is only 200 mg/day. This is because, after ingestion, a portion of adrafinil remains as inactive modafinilic acid and is not converted to modafinil, giving adrafinil a lower milligram-for-milligram potency.
The difference in potency between modafinil and adrafinil is supported by anecdotal evidence from smart drug users.
Historically, Olmifon fell into clinical disuse following the introduction of “Modiodal” (modafinil) and was discontinued in 2011, suggesting that modafinil is more effective in treating sleep-wake disorders such as narcolepsy.
With the sole exception of Australia, where adrafinil is an "S4" prescription-only drug, adrafinil is either unclassified or classified as "reference material" in almost all countries.This means that researchers may find that adrafinil is easier to access than modafinil for use in experimental settings. Increased competition between suppliers is one of the main reasons why adrafinil is often cheaper than modafinil.
Adrafinil is slower acting than modafinil
Modafinil works much faster than adrafinil and typically takes 30 to 60 minutes to take effect, compared to 1 to 2 hours for adrafinil. For example, patients who have been prescribed modafinil for shift work sleep disorder (SWSD) are recommended to take one 200 mg tablet one hour before the start of the shift.7]. Anecdotal evidence from users suggests that adrafinil acts more slowly than modafinil (due to the way it is metabolized) and typically takes around two hours to take effect.12].
Where to buy Adrafinil online | Guide 2023
If you are looking to buy adrafinil, this is the section for you. Although adrafinil is widely available as “reference material,” you won't be able to find it for sale in supplement stores. To buy some, you will have to connect to the Internet.
We have reviewed the top suppliers in the market and evaluated them in terms of prices, quality, delivery speed and reliability. The main supplier? Science.bio.
PS order your Adrafinil today!
Does Adrafinil make you high? | Verdict
If you were curious about whether adrafinil produces a “high,” hopefully this guide has answered all of your questions. As you can see, adrafinil is a wakefulness-promoting drug that offers over 12 hours of increased concentration. Far from making the subject feel "high", it appears to provide a long, smooth "burst" of energy and productivity, without any "crash" as would occur with other stimulants.
Overall, research on adrafinil suggests that it has potential as a cognitive enhancer with relatively minor side effects. If you are considering trying this medication, be sure to consult our recommended supplier for the purest form of adrafinil on the market.
