Adrafinil | Review of uses, side effects and more

Curious to know if this nootropic really works? Then keep reading this. Adrafinil Review.

Now…

Why would we look for Modafinil analogues, when Modafinil itself provides all the focus and focus one could ever need?1]?

It's that simple:

It is much easier to order Ardafinil online than other nootropics.

Because? Because Adrafinil is 100% legal and is sold without a prescription in almost all countries. Additionally, it is a nootropic that can safely and reliably improve daily mental performance. Yes, Adrafinil really works.

But there is more than that, that's why we started thinking about the Adrafinil versus modafinil battle…

Is Adrafinil a superior nootropic to Modafinil? Is it safe for me to take? Is Adrafinil worth the price compared to other smart drugs? Is Adrafinil a legitimate cognitive booster or a waste of time and money?

To answer all those questions, our team started researching and testing. It's not enough for Adrafinil to simply "work": the nootropic has to provide a significant return on investment with respect to productivity and energy.

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What is adrafinil?

Adrafinil actually has an interesting story behind it!

It was first synthesized in 1974 by a French pharmaceutical company called Louis Lafon Laboratories. Adrafinil was branded "Olmifon" and launched on the French drug market in 1985 to treat narcolepsy.

Louis Lafon Laboratories was purchased by a larger company called Cephalon in 2001, which voluntarily removed Olmifon from the market in 2011 and stopped manufacturing the drug.2].

But why would this happen?

Why would Adrafinil, a wakefulness-promoting drug that has no side effects seen with other stimulants, such as addiction, increased blood pressure and heart rate, be suddenly withdrawn?

Scientists quickly discovered that Adrafinil is a prodrug of Modafinil, and that's where the Modafinil story began!

To simplify the science, a prodrug is an inactive drug that the body metabolizes (converts) into a biologically active drug.

In the case of Adrafinil, its main metabolite is none other than Modafinil itself. The only difference between the two from a structural point of view is that Adrafinil has a hydroxyl (OH) group at the amino terminus of the molecule.

Both Modafinil and Adrafinil offer the same cognitive benefits [3]:

• Reduction of mental fatigue,
• Increased short and long term memory,
• Improved ability to think clearer thoughts.
• Higher energy levels throughout the day,
• elevated mood,
• Ability to stay awake for much longer and
• There is no "energy crash" as seen with other traditional stimulants.

However, Modafinil was found to be more potent and faster acting than Adrafinil. Lasts much longer and requires a lower dose [4].

Because Modafinil is a much more effective drug, there was little financial incentive for pharmaceutical companies to continue making Adrafinil.

Like Modafinil, we do not understand the exact mechanisms through which Adrafinil exerts its effects on the human brain.

However, researchers in the medical community are aware that Adrafinil is not a traditional stimulant, primarily because it acts selectively on the amygdala and hypothalamus of the brain.5].

But enough of the history books. Does Adrafinil really work like its more famous successor?

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Does Adrafinil really work? | Our experience

we already compare Adrafinil to Modafinil in a previous blog post, so if you're interested in digging deeper, you should definitely check it out.

When it comes to Adrafinil versus Modafinil, here's what our team found...

Both drugs gave us the intense concentration we needed to maintain maximum productivity for several hours. We did not experience any side effects or addictive tendencies with either of these two smart drugs.

Adrafinil took two hours to take effect, compared to one hour for Modafinil. And although Modafinil lasted about 12-15 hours, we only felt the effects of Adrafinil for a few hours, maybe 6-8 hours total.

So when we took Adrafinil in the afternoon, we could still fall asleep at night without having to stay awake. We didn't have the same result with Modafinil and were restless all night.

While Modafinil is definitely more potent and effective, we can seriously say that Adrafinil really works and does what it is supposed to do.

But not all nootropic users had the same experience as our team members.

Due to the large amount of time it takes Adrafinil to metabolize into Modafinil, some users report waking up much earlier to take their Adrafinil dose. This helped them use Adrafinil without disturbing their circadian rhythm.

In a discussion we found on Reddit, there were mixed reviews [6]. One user reported a lack of noticeable effects when using Adrafinil:

“I think Adrafinil is one of those things that doesn't work for some people. I have never received it from [anonymous supplier], but I have tried it elsewhere and in higher doses and all it did was give me insomnia. No concentration, no energy, nothing.”

Another user said Adrafinil was only effective when he was sleep deprived:

“For me, if I take it after a good night's sleep, I really notice very little. But if I'm out until four in the morning and I have things to do the next morning, I notice it and it's really just kind of a sensation. of lucidity, not really motivating.”

So, does Adrafinil really work?

In theory, it should be that way because of how it works in the body. In practice, everyone is different and results vary. The only sure way to know is try adrafinil for a few weeks and see how you react.

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Benefits and effects of Adrafinil | top 5

Before you jump into buying Adrafinil, let's take a look at what science has to say about this little-known nootropic.

A quick Search in PubMed using the query “adrafinil” will reveal only 38 results, which is not very impressive.

This is because most of the studies related to Adrafinil were carried out in the 1980s and 1990s by French scientists, whose publications are currently not available in any online database.

So, everything we know about Adrafinil is either derived (a) from the first-hand experience of smart drug users or (b) based on the proven effects of Modafinil in several studies.

That said, there are still many established cognitive benefits of using Adrafinil...

• Adrafinil increases your energy

The main benefit of Adrafinil has to be its ability to give you more energy, especially when you feel fatigued and tired.

This, in turn, allows you to maintain a higher level of concentration for a longer period of time.

The "wake-promoting" effect of Adrafinil was confirmed in studies conducted 20 years ago in which dogs were given different doses of Adrafinil [7]:

Adrafinil produces increases in locomotor activity in elderly dogs. The magnitude of the increase depends on the dose and the environment. The effect persists for some time after administration and efficacy does not decrease with repeated administration.

And when Adrafinil was administered to rhesus monkeys, their nocturnal activity increased up to 4-fold without any sedative effect occurring when the drug wore off [8].

We don't know exactly why Adrafinil makes you so alert and does such a good job of keeping drowsiness at bay.

But one possible explanation is that Adrafinil increases the production of hypocretin, a neurotransmitter deficient in patients with narcolepsy.9].

Another possibility is that the awakening simply comes from the conversion of Adrafinil to Modafinil, which is a proven “eugeroic.” Laboratory tests on rats have shown that modafinil increases "histamine" levels in the brain.10] and other studies have shown that higher amounts of histamine can definitely help promote alertness and concentration [11].

• Adrafinil positively improves your mood

Adrafinil will not only lead to better cognition, but it will also improve your mood and cause an unexplained increase in motivation.

It is difficult to say whether motivation is created first or whether the ease of work associated with taking Adrafinil leads to an increase in motivation.

There is not much on this topic in the scientific literature, which points to some preliminary results taken from case studies [4]:

“There is some evidence that adrafinil affects basic motivational states.

According to Saletu et al. (49), two subjects reported experiencing interest in sex for the first time in years after taking adrafinil.

Nicolaidis and de Saint Hillaire (45) found a decrease in eating and body weight after treatment with modafinil.”

So if you are a student who struggles to study for long hours or has trouble staying on track during boring and sometimes repetitive classes, Adrafinil might be worth a try!

While we don't know exactly why Adrafinil improves mood, we do know that it is a prodrug of Modafinil, so it shares many of the same effects. Studies have shown that modafinil increases dopamine in the brain [12], and science tells us that elevated levels of this neurotransmitter can lead to elevated mood. [13].

• Adrafinil may lead to better brain health

Depending on the effects of Modafinil, Adrafinil may not only improve productivity.

It can be used as a neuroprotectant to protect against harmful neurological diseases and processes.14]:

“The possible therapeutic implication of the use of modafinil in the elderly can be anticipated especially when considering cognitive deficits dependent on aging or Alzheimer's disease (AD).

…Therefore, on a speculative note, the modafinil-driven [functional connectivity] effects that we report occurring in areas that control attention and inhibitory control may help counteract the deficits of the aging brain, as well as in the brain of [mild cognitive]. disability] or patients with AD.”

Not surprisingly, Adrafinil was initially targeted at elderly patients suffering from depression caused by neurodegenerative disorders.

But for a healthy person, Adrafinil can help keep the brain alert and fully functioning well into old age.

• Adrafinil can improve memory

This one is a bit of a stretch and requires us to go back to canine studies [4]:

“…we trained elderly beagle dogs on size and intensity discrimination learning tasks, and training sessions were conducted 2 hours after treatment with 20 mg/kg adrafinil or a placebo control.

...Adrafinil treatment produced a significant improvement in learning, as indicated by a decrease in both errors and criterion trials.

“This improvement also appeared to be related to baseline cognitive function: dogs with the most severe impairment appeared to show the greatest improvement.”

Based on our experience, we cannot say with certainty whether Adrafinil directly leads to an improvement in memory.

However, directly improving various mental qualities (concentration, motivation, energy, etc.) can indirectly lead to greater retention of complex information.

• Adrafinil could improve reaction time

With all of the above benefits going for you, you will notice that your reaction time is drastically shortened when you take Adrafinil.

Your fingers type faster on the keyboard. You can react quickly in challenging situations without veering into pure impulsiveness.

Again, we need to look at a study involving Modafinil to come to this conclusion [15]:

“Middle-aged female rats (18 to 20 months old) were administered oral doses of modafinil (0, 8, 32, and 64 mg/kg) and tested in a 3-hour sustained attention and visual discrimination task. options.

“Modafinil produced a dose-dependent pattern of greater response accuracy and impulse control (fewer premature responses) and shorter response latencies, without affecting omission errors, motivation, or motor control.”

You will notice the same thing with Adrafinil, but only when its effect is maximized. This means that you may have to wait until Adrafinil fully takes effect.

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Adrafinil Ideal Dosage Guide

So which one is the BEST? Adrafinil dosage For anyone looking to get a lot of work done?

To answer that question, we need to understand exactly how Adrafinil is metabolized in the body [16]:

“Adrafinil peaks in the blood of elderly people approximately one hour after oral ingestion, although neurological effects occur primarily after this peak due to the time it takes to convert it to modafinil, its active metabolite.

Adrafinil can be metabolized to modafinil, which is then metabolized to the inert modafinilic acid or modafinil sulfone. Adrafinil can also be metabolized directly to modafinilic acid without producing modafinil.”

This is what it all means...

Not all Adrafinil is converted to Modafinil and some is lost in the metabolization process.

Since the prodrug Adrafinil takes time to break down into the active drug Modafinil, naturally, its cognitive effects will take longer to appear.

Modafinil usually peaks between 60 and 90 minutes, so add about an hour more for Adrafinil.

Plus, the effects won't last as long.Adrafinil will give you a milder increase in concentration for 2 to 3 hours, as opposed to the 10 to 12 hours you get with Modafinil [17].

Therefore, you will need MORE Adrafinil to confer the same cognitive effects as Modafinil.

(NOTE: All of the above depends completely on your body chemistry and the dose of Adrafinil you take)

A good rule of thumb is to take 300 mg of Adrafinil for every 100 mg of Modafinil you want to "experience."

As we know, most people do well with 100-200 mg of Modafinil per day [18], this means your could take between 300 and 600 mg of Adrafinil [17]. However, if you are taking it for the first time, we suggest starting with 300 mg.

Based on our experience with the use of Adrafinil, this is what we recommend…

• Ideal Dose: 300 mg once a day, can be divided into two smaller doses
• When to take it: First thing in the morning to avoid problems falling asleep at night
• What to take it with: A glass of water just before breakfast, as food can prolong the time it takes for Adrafinil to work.

We recommend taking Adrafinil no more than 3 times a week in evenly spaced doses.

If you are using Adrafinil with Modafinil, take Modafinil 1-2 days within a week and Adrafinil 1-2 days within the same week.

At most, you should use it cyclically “one week on, one week off” (or as needed) to avoid raising liver enzymes.

And for the same reason, we do not recommend taking Adrafinil daily for a long period of time.

If you are feeling cautious, you can even start with 150 mg of Adrafinil per dose and increase gradually.

Due to the long metabolization process, you WILL have to take Adrafinil sooner than you would normally take Modafinil.

Follow these rules and you will have no problem dosing Adrafinil safely and effectively.

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Where to buy Adrafinil online? | Guide 2023

So where exactly should you buy Adrafinil and what is the best online supplier to help you get this nootropic?

First, know that we are very selective about where we buy Adrafinil online or any smart medicine.

For us to recommend a supplier, they must be reliable, offer fair shipping prices to numerous countries, and provide a great customer experience.

And no other Adrafinil supplier meets our needs better than Absorb your health.

These guys have a lot of reputation and have been in the nootropics game since 2011.

Here are some of the things we believe make them the number one Adrafinil provider online:

• Rigorous third-party testing: Every product we've seen on their site comes with test results from independent laboratories to verify its identity and purity, including Adrafinil. It's no surprise that they have some of the highest quality Adrafinil out there.
• International shipping to over 100 countries: There is a good chance that Adrafinil will be shipped to your country. And you get FREE shipping when your order is over $75. All orders ship within one business day.
• Several five-star reviews: We've only heard great things about Absorb your health of the people who have bought from them. Many of them are regular and loyal customers. We placed many orders with them and never had any problems.
• Fair Return Policies: US domestic customers may return their purchase within 90 days of their order for a full refund. You can also get a refund OR replacement if your order does not arrive due to a USPS issue.
• Numerous payment methods: All major credit cards are accepted. Absorb your health, so paying for your order will be easy and secure.

The only thing we don't like Absorb your health is that they do not offer refunds for international orders unless the shipment clears US customs.

Outside of these small comforts, we highly recommend Absorb your health as a reliable supplier of Adrafinil.

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How to order Adrafinil in your country

Adrafinil is currently an unscheduled and unregulated medication in most countries. This means you can buy it legally without a prescription.

However, you won't be able to find it at your local pharmacy or supplement store. You must order it through an online provider such as Absorb your health.

If your chosen online supplier does not ship to your country, you will need to find an alternative supplier.

We know for sure that you will have no problems using Adrafinil in countries like the UK, Canada and the USA.

We cannot speak for other countries, so you will need to check the laws in your country and determine if you can legally purchase and use Adrafinil where you live.

Some countries may require that you have a prescription for Adrafinil.

But as long as you are using Adrafinil for yourself and not trying to sell it for profit, you will be fine.

This makes Adrafinil a fantastic legal alternative to Modafinil, which requires a prescription to use in most countries.

A final note: Adrafinil is prohibited by various anti-doping organizations such as WADA, USADA and the NCAA.

So if you are a competitive athlete reading this, make sure you do NOT use Adrafinil to improve your performance!

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Stacking Adrafinil with other nootropics?

Adrafinil is amazing on its own, but can it be combined with other smart drugs to achieve a spectacular synergistic effect?

One in which Adrafinil's positive attributes are amplified while its side effects are reduced or eliminated, or even a separate part of cognition is improved?

We think it's entirely possible, so here are some stacks worth trying:

• Adrafinil and Noopept

Noopepto It combines well with Adrafinil for laser focus and extreme concentration for several hours.

This Russian nootropic is perfect when you have an all-nighter ahead of you or a very difficult task that requires 100% of your attention.

It also has the pleasant effect of reducing anxiety, helping you stay calm and grounded while you work.

20-30 mg is what we recommend taking along with Adrafinil.

• Adrafinil and milk thistle

Milk thistle is a natural extract that will counteract any potential damage caused to your liver when taking Adrafinil.

This is a combination we recommend to improve your overall health, rather than increase your cognitive performance.

Take 75-150 mg of milk thistle with Adrafinil for best results.

• Adrafinil and Piracetam

piracetam It will do wonders for your memory while improving the speed at which you process and learn new information.

Some people find that they are more creative when taking these two together, but we have found that this combination is more neuroprotective than anything else.

The ideal dose of piracetam to take with Adrafinil is 4 to 5 grams, once or twice a day.

• Adrafinil and caffeine

This is a “wild card” stack, as it can work for you or against you.

Some people will be much more alert and focused when combining Adrafinil and caffeine. Others will feel anxious and nervous, and some atypical cases will report faster heartbeats and higher blood pressure.

If you try this combination, we would limit your caffeine supply to 1 or 2 cups of coffee early in the morning when taking Adrafinil.

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Adrafinil In-Depth Review | Verdict?

So what can you take away from this deep dive? Adrafinil Review?

We believe that Adrafinil is a very powerful smart drug that can be used by healthy people who want to achieve supreme levels of productivity.

However, it would not be our first choice if we had direct access to Modafinil. We still consider it to be the BEST nootropic in the world.

While Adrafinil has been discontinued for several reasons mentioned in this article, it is a 100% legal and cheaper alternative for people who cannot get Modafinil.

Consider Adrafinil as another option when option number one is not available. It still works like a charm and does wonders for anyone who has a stressful high performance career.

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