flmodafinil review | Review of benefits, side effects and more

This flmodafinil review will tell you everything you need to know about the promoted analogue of Modafinil.

The few people who were brave enough to try this experimental drug claim that it is more effective than modafinil in improving cognition, while being cheaper to buy and safer with regard to side effects.

But it will be extremely difficult to find scientific studies or published information from legitimate sources.

Which raises the last question...

Is Flmodafinil a dangerous research chemical or the true successor to Modafinil and its cousins? Armodafinil and Adrafinil?

Also, what is the best dose of flmodafinil to take? What are the side effects of flodafinil? And where can you buy flodafinil online?

This definitive Flmodafnil guide will answer all of the above questions and many more in complete detail!

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flmodafinil review | General description

Flmodafinil (also known as Lauflumide, NLS-4, CRL-40,940) It is an experimental analogue of modafinil that has a chemical structure very similar to that of the original drug [1]:

As you can see, Flmodafinil has a fluorine atom added to the "p" position of each benzyl ring in Modafinil. For this reason, scientists refer to flmodafinil as the "bis(p-fluoro)" analogue.

Not much more can be said about Flmodafinil, but many researchers have claimed that Flmodafinil has the following properties:

• It has eugeroic (that is, wakefulness-enhancing) properties similar to those of modafinil.
• It affects the same neurotransmitters as modafinil: glutamate, dopamine, histamine, etc.
• It exerts more powerful effects than modafinil with respect to mood, memory, alertness, and overall productivity.
• It enters the bloodstream faster than Modafinil and begins to “act” much faster

Unlike modafinil, flmodafinil is NOT approved by the FDA to treat the same three medical conditions as modafinil: obstructive sleep apnea, narcolepsy, and shift work sleep disorder.2].

However, this has not stopped biohackers from using Flmodafinil in the hopes of discovering a superior and more potent version of Modafinil.

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Benefits

What cognitive benefits of Flmodafinil can we deduce from the few scientific studies available and the numerous testimonials from nootropic users who took a huge leap of faith when using Flmodafinil?

Let's find out…

Flmodafinil will make you more alert

This is the only case where we have a published study in mice demonstrating the alertness-enhancing properties of flmodafinil [3]:

“NLS-4 [i.e. [Flmodafinil] at 64 mg/kg induced a significantly longer duration of wakefulness than modafinil at 150 mg/kg. "

“…Our results indicate that NLS-4 is a very potent drug that promotes wakefulness without signs of rebound hypersomnia.

Unlike modafinil, recovery sleep after NLS-4 treatment is characterized by lower NREM and delta activity, suggesting a reduced need for recovery despite longer drug-induced wakefulness.”

As we have written previously, Flmodafinil is a great alternative to modafinil for getting 6 hours of pure laser focus.

This benefit is by far the most common observation from human research subjects who have used Flmodafinil [4]:

“…Flmodafinil, completely legal, gives me approximately 12 hours of wakefulness and also increases my awareness. It is also not a stimulant, so it does not cause an increase in heart rate or nervousness.”

Put another way, flmodafinil is not a traditional stimulant in the sense in which we think of it. You may not directly “feel” more energetic, but you will subtly feel yourself becoming more focused and productive.

Flmodafinil reduces daytime fatigue

While Modafinil is not approved by the FDA to treat fatigue, many patients with medical conditions in which fatigue is a major symptom feel much less tired if they take 200 mg of Modafinil daily.5].

Flmodafinil users have noticed the same effect, stating that it helps them overcome bad habits such as procrastination and other impulsive behaviors that are often destructive.6]:

“I slept badly the night before. Maybe a total of 4 hours on and off... I took the recommended starting dose of 50 mg. It had a sweet/somewhat metallic taste. I didn't like the taste but it was definitely tolerable.

Within 10 minutes I started to feel less tired, much less tired. Within 20 minutes I was not tired at all. “I felt like I had just woken up after getting a good night's rest.”

With Flmodafinil removing the burden of dealing with a condition that robs you of your mental energy, it becomes much easier to make better decisions throughout the day.

Fmodafinil will not interfere with your sleep schedule

Although there is limited pharmacokinetic data available for Flmodafinil, anecdotal evidence suggests that the wake-enhancing effects of the experimental nootropic do not come at the cost of interfering with your sleep schedule.7]:

“On days when I don't need stimulation throughout the day, I prefer Flmodafinil due to its shorter duration.

I can fall asleep much easier compared to Modafinil which keeps me awake almost all night. “Flmodafinil also appears to have more mood-enhancing benefits.”

This is explained by the more potent but shorter duration of flmodafinil. You'll get a greater cognitive boost for 6 to 7 hours before the effects of the medication wear off, just in time for a good night's sleep.

Flmodafinil provides a positive boost to overall mood

In both scientific studies and personal testimonials, Modafinil can positively improve your mood and have a slight effect on your overall happiness [8].

The same appears to be true for flmodafinil, and possibly more so than modafinil [9]:

“Definitive increase in the state of alert. No anxiety or nervousness (note: benzos play a role). It improves mood, but nothing like a good amphetamine high. Clear head.

No brain fog yet, which is surprising given the benzos and lack of sleep. There is no greater desire to socialize, but socializing is easy. General feeling of satisfaction, but far from happiness.”

The encouraging feelings of motivation that come from Flmodafinil will be very helpful for anyone facing an almost impossible workload and tight deadlines.

Fmodafinil produces less "jitters" than modafinil

For people who find Modafinil to be too overstimulating, a possible first impression could be that Flmodafinil would be even worse.

But for some strange reason, many nootropic users find that flmodafinil's supposedly higher level of potency does not cause jitters or anxiety.10]:

“Concentration and energy have increased 100%. The focus is 100%... There's no euphoria with this, it's just Awake, alert, focused and fucking energetic!

Jesus, I have killer energy hahaha. There are NO side effects like caffeine would bring, my heart rate is normal, etc. “I don’t feel nervous or anxious, nothing, just pure energy.”

This positive effect is one of the many reasons why we recommend Flmodafinil as a more legal alternative to Modafinil... whether for those who cannot access it or for those who find that Modafinil does not provide them with the benefits they seek. .

Fmodafinil may be useful for people with ADHD

This is NOT a direct recommendation to start using Flmodafinil for the treatment of ADHD symptoms. However, some people diagnosed with ADHD who have experimented with flmodafinil have reported the following effects [11]:

“It is now 11 in the morning and I took the 75 mg dose at 7 in the morning. At this point I can comfortably say that I feel emotionally stable and focused like I do on 10 mg of Ritalin IR at 7am. m. and then another at 11 a.m. m.

The biggest differences are... there is no anxiety or feeling of rush. No nervousness or sensations of CNS stimulation. At this point I have also consumed about 200 mg of caffeine. So far no side effects have been observed.”

Overall, Flmodafinil appears to be a suitable alternative to Armodafinil and Modafinil for people who want a stronger cognitive boost with a smaller dose without some of the effects associated with both medications.

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Side effects and safety of flmodafinil

Considering the lack of scientific research seen so far, you may be curious about the side effects of flmodafinil or whether it is safe to use to improve cognition.

NOTE: There are no toxicology studies, human studies, or clinical reviews of flodafinil. You are 100% responsible for any effects, good or bad, that arise from the responsible use of Flmodafinil.

From the testimonies we were able to collect, it seems like the side effect profile of modafinil It is very similar to Flmodafinil.

These are the most commonly reported side effects of flmodafinil:

• Dehydration [12]
• Headache [13]
• Irritability [14]
• Anxiety [15]
• Nausea [16]
• Lack of significant effects [17]

In general, you should use Flmodafinil in the same way that Modafinil is properly used. This ensures that the side effects described are short-lived and mild in intensity.

We have previously written about use modafinil safely, and our recommendations will be repeated here for the proper use of Flmodafinil:

• Use Flmodafinil only once or twice a week as needed, for up to 30 days before taking a 7-day break to reestablish your tolerance levels.
• Your daily dose of Flmodafinil should not exceed 100 mg, and beginners are recommended to start with 50 mg before slowly increasing.
• We do NOT recommend combining Flmodafinil with other nootropics due to its high potency [18]
• Drink more water than usual if you take flodafinil; 2 to 4 liters on the same day are highly recommended.
• Take Flmodafinil only in the morning; between 8 and 9 a.m. m.are the best times to use Flmodafinil

If you follow the recommendations listed above, you will be able to use Flmodafinil safely.

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Legality

Is it legal to buy and use flodafinil? To summarize: it is not exactly the same legal status as modafinil.

In the United States, Modafinil is a Schedule IV prescription medication. That means it is illegal to use without a prescription and you are not allowed to share Modafinil or sell it to anyone.

But as you already saw in the introduction, Flmodafinil is an ANALOGUE of Modafinil.

And for those of you wondering if the infamous “Federal Analogues Act” passed in 1986 applies to flmodafinil, it does not [19]:

“…[the law allows] any chemical substance “substantially similar” to a controlled substance listed in Annex I or II It should be treated as if it were included in Schedule I, but only if it is intended for human consumption.

In other words…

Flmodafinil is an uncontrolled and unregulated research chemical on the somewhat legal gray market that is not approved by the FDA for human use.

For this reason, you will see online providers advertise Flmodafinil as follows:

“This material is sold for research purposes only. It is not intended for human consumption, medical uses, household uses or veterinary uses.”

But from our personal experience and having access to thousands of users who have used Flmodafinil, here is a short cheat sheet that tells you what all of the above means:

• Flmodafinil will NOT appear in a drug test for modafinil unless specifically evaluated by the examiner
• While you can technically travel with Flmodafinil in small quantities, its gray market status puts you at slightly greater risk than take modafinil on a plane
• You can buy Flmodafinil online in small quantities without a prescription in the same way as Modafinil can be bought online
• It is 100% illegal to SELL flumodafinil to others due to its status as a research chemical [20]

In short, you are responsible for the proper use of Flmodafinil and any legal ramifications that arise.

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Pharmacology

Researchers have speculated that the main mechanism of action of flmodafinil is very similar to that of modafinil, if not identical.21]:

“Modafinil appears to be able to increase extracellular dopamine levels in the nucellar accumbens and prefrontal cortex of the rat and in the caudate nucleus of the dog.

It has been shown to occupy both dopamine and norepinephrine receptors (in the striatum) and prevention of dopamine receptor occupancy abrogates sleep-promoting effects in mice, suggesting that this mechanism of action is crucial for sleep-promoting effects.

Modafinil works by binding to the dopamine transporter (DAT) and inhibiting the uptake of dopamine, which is why it is known as a dopamine reuptake inhibitor (DRI).

The only published study on the pharmacological properties of flmodafinil reveals that it is 2 times more potent than modafinil in inhibiting dopamine reuptake.22]. In other words, 50 mg of Flmodafinil would be as effective as 100 mg of Modafinil in producing the same result.

Unpublished data also indicate that flmodafinil's ability to bind DAT is "greater than that of methylphenidate and without deleterious effects on peripheral adrenergic systems implicated in hypertension" [3].

Applying this data to practical use, many users claim that Flmodafinil takes between 30 and 60 minutes before taking effect and lasts a total of 6 to 7 hours. For this reason, flmodafinil is likely to have a shorter half-life. compared to 12-15 hours for Modafinil.

However, the real interest in Flmodafinl's supposedly superior potency compared to Modafinil comes in the form of two additional fluorine atoms.

It is common knowledge among medicinal chemists in the pharmaceutical industry that adding additional fluorine atoms to medications can cause the following changes:23, 24, 25, 26]:

• Increased lipophilicity (i.e. improved ability to dissolve in fats, therefore improved ability to penetrate cell membranes)
• Decreased rate of drug metabolism (i.e., less drug is removed from the system through enzymatic breakdown)
• Better penetration of the blood-brain barrier
• Increased bioavailability (that is, the fraction of a drug that reaches the bloodstream)
• More effective binding to its target receptor.

Flmodafinil is a perfect example of how seemingly subtle changes in the chemical structure of a drug can radically change its properties. This could be the reason why several nootropic users claim that Flmodafinl is a more effective version of Modafinil.

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Where to buy flodafinil online | 2020

So where can you buy flodafinil online without having to worry about product quality or shipping issues?

After thoroughly reviewing the few suppliers that have flmodafinil in stock, only one candidate met our strict requirements...

Science.bio is without a doubt the best place to Buy high quality flodafinil online.

Despite being a younger company, formerly known as IRC.bio, they have managed to establish themselves as a highly reliable supplier of premium nootropics such as Flmodafinil and many others;

Here's what you can expect when you order flodafinil from Science.bio...

Excellent client service

His communication with his clients is timely and professional.Having submitted several queries ourselves, we were impressed by how quick and helpful their responses are.

This is directly reflected on their TrustPilot page, where they have a rating of 4.5/5 out of 25 reviews at the time of writing. The review below is a good summary of what you can expect from this provider [27]:

“Highly recommended for reliable research products and fast, exceptionally helpful customer service... Since then, I have been satisfied with several orders each month.

Consistent quality with a wide variety of secure payment methods to work with. Many special offers and coupons may also be available for all types of customers throughout the year.”

Total transparency on product quality

According to the official website, all Science.bio products are "rigorously verified by PhDs in organic and analytical chemistry, including NMR, FTIR, polarimetry, HPLC and LC-MS analysis."

Each product comes with a comprehensive data sheet, along with full audits of its production batches and product potency evaluated through an independent Certificate of Analysis (CoA).

Considering flodafinil's status as an experimental drug, this information is mandatory for any consumer concerned about their own safety.

FAST shipping times

All orders on Science.bio are shipped within 24 hours and a tracking number is immediately provided.

NOTE: Realistically, you should allow a time period of 1-3 days due to the current situation involving the COVID-19 pandemic.

We highly recommend stocking up on Flmodafinil and other products as FREE first class international shipping is offered to customers who place an order over $300.

Your order will come in discreet packaging, so you'll never have to worry about prying hands or nosy neighbors asking about your private life.

And in case you don't receive your product due to customs issues or the product arrives defective, Science.bio offers a 30-day 100% money back guarantee.

Numerous payment methods

One of the main problems with online nootropic sellers is that there are very limited options for completing the payment.

Fortunately, Science.bio accepts several options to suit its customers and their needs:

• Credit card (Visa, MasterCard)
• electronic check
• Bank transfers
• Bank transfers
• Bitcoin (Save 5% on your total order price)

Based on our conversations with test subjects, this list covers 99% of the most common payment methods.

Fair prices for premium flmodafinil

You may be wondering how much flmodafinil costs compared to modafinil price.

Science.bio offers Flmodafinil in two forms:

• A 50 mg/ml liquid solution – gives you 30 doses in total, which is equivalent to $2USD per dose
• A 5 g bottle of powder – offers you 100 doses in total, which is equivalent to $1.50 USD per dose

If you compare it to the cost of buying Modafinil online, you would pay $1.61 per 200 mg dose of Modafinil if you buy 30 tablets at a time.

This makes Flmodafinil cheaper or more expensive than Modafinil, but by a small amount depending on the formulation you purchase.

All in all, Science.bio is the number one supplier of flmodafinil And we highly recommend them!

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History of filmodafinil

Flmodafinil was supposedly discovered along with Modafinil in the late 1970s when dr.Michel Jouvet of Lafon Laboratories was researching novel treatments in the field of sleep medicine.

The first published instance of Flmodafinil can be found through its supposed precursor drug Fladrafinil (also known as CRL-40,941, adrafinil with two additional fluorine atoms). A patent filed in 1984 by the pharmaceutical company noted the following properties of Fladrafinil [28]:

• A maximum non-lethal dose of 1024 mg/kg in mice
• Antiaggressive effects in mice that received a dose of 256 mg/kg
• Reduces the duration of sleep induced by barbiturates at doses of 64 and 128 mg/kg.
• Better overall bioavailability than Adrafinil when taken orally

The final statement of this patent was quite interesting:

“From a clinical point of view, CRL 40941 acts at doses that are half those of CRL 40028.

Excellent results were obtained in man when administered orally, at a rate of 2 to 3 capsules or tablets (each with 50 mg of active ingredient) per day, particularly for 2 to 8 weeks in the treatment of hypersommia and psyasthenia.”

In 1986, Lafon Laboratories filed another patent, this time investing in both Flmodafinil and Fladrafinil. These are some of the observations they made in mice that were administered Flmodafinil [29]:

• Improves motor activity and recovery.
• Reduces the duration of sleep induced by barbiturates at doses of 32 and 128 mg/kg.
• “It gives excellent results as an exciting medicine”

Then flodafinil disappeared out of nowhere, until 2013, when NLS Pharmaceuticals filed a patent for flodafinil under the name "Lauflumide" [30]. This occurred a year after generic drug manufacturers were granted the ability to produce Modafinil [31].

Unlike previous patents, this one made several extraordinary claims about lauflumide's potential to be used as a therapeutic treatment for ADHD symptoms:

• "Lauflumide (racemic mixture) has an expected efficacy in plasma of 6 to 7 hours."
• Lauflumide is at least as effective as methylphenidate (Ritalin) and more effective than modafinil in “improving waiting ability in young Wistar rats subjected to the T-maze test” (a protocol used to assess impulsivity and therefore the effectiveness of ADHD medications).
• "[Lauflumide] is 20 times more effective than adrafinil and 4 times more effective than modafinil."

Flmodafinil was subsequently investigated in a Phase I clinical trial started in 2015 involving patients with Alzheimer's disease, but was discontinued in late 2019 for unknown reasons.32].

This is the last historical mention of Flmodafinil from any reliable source. Since then, no further research has been conducted on Flmodafinil or its potential therapeutic applications.

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flmodafinil review | Verdict

So what can be concluded from this exhaustive flmodafinil review?

Despite its status as an experimental research chemical, there are a significant number of users who claim that Flmodafinil is an improved general version of Modafinil.

More powerful, cognition-enhancing effects, safer to take, easier to obtain, cheaper to buy, and a must-have for shorter periods of incredible productivity and sharp focus.

But not everyone will agree with the above statements and some people may not get the response they are looking for when taking flodafinil.

The potency of flodafinil, therefore, is completely individual to the user and their unique biochemical composition.

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