Hydrafinil | Review of benefits, side effects and more

Curious about hydrafinil?

You have come to the right place.In this Hydrafinil Review, we will offer an overview of this nootropic, from its supposed benefits and side effects, to where to buy them online.

Hydrafinil is a "eugeroic" that has been shown to promote alertness and wakefulness. It is cheaper to buy than Modafinil and anecdotal evidence suggests that it causes fewer side effects.

However, you will be hard-pressed to find peer-reviewed scientific studies or published information about this exciting new cognitive stimulant.

This raises some very important questions...

Is hydrafinil safe for research subjects? Is it a powerful concentration enhancer, even surpassing Modafinil and its cousins? Armodafinil and Adrafinil in terms of effectiveness?

In this guide, we'll address both of these questions and more, including:

• What could be the best dose of Hydrafinil to administer?
• What side effects can Hydrafinil cause?
• Where can researchers buy Hydrafinil online?

So if you're curious about Hydrafinil and what it can do for you, read on!

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Hydrafinil Review | General description

Hydrafinil (also known as 9-fluorenol, 9-hydroxyfluorene, fluorenol) It is an analogue of modafinil that acts as a weak inhibitor of dopamine reuptake [1].

While Modafinil and Hydrafinil may not appear to share many structural similarities, they are very closely related to each other. As noted by Dunn et al. In their work to find new derivatives of Modafinil, studies have indicated that Hydrafinil is 39 percent more effective than Modafinil in promoting wakefulness in rats [2].

While peer-reviewed studies on hydrafinil as a nootropic are virtually non-existent, researchers have indicated that it has the following properties:

• It has shown eugeroic (i.e. wakefulness-enhancing) activity similar to that of modafinil;
• It affects the same neurotransmitters as modafinil (i.e. glutamate, dopamine, and histamine);
• It is potentially more effective than Modafinil with respect to mood, memory, alertness, and overall productivity.

Unlike modafinil, hydrafinil is NOT approved by the FDA or used to treat any of the sleep-related disorders for which modafinil is typically prescribed, including obstructive sleep apnea, narcolepsy, and occupational sleep disorder. by turns.3].

Hydrafinil's status as an unregulated investigational drug has sparked researchers' interest in hydrafinil as a potentially safer and more effective alternative to modafinil.

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Hydrafinil Benefits

Now that you have a basic idea of ​​what hydrafinil is, let's focus on some of its purported cognitive benefits.

Since studies focusing directly on hydrafinil are lacking, we are left with mostly reports and anecdotal studies on similar compounds such as modafinil and adrafinil.

Hydrafinil potentially increases alertness without 'jitters'

The aforementioned study by Dunn et al., designed to determine the next generation of wake-promoting supplements, appeared to attribute Hydrafinil's activity to increased alertness in rats [2]:

“As shown in Table 1, in further evaluation in a wake stimulation assay in rats, compound 3 (compound 3 is hydrafinil, 100 mg/kg ip) was found to be active. Therefore, the wake-promoting activity of compound 15 in rats is likely to have arisen from the activity of compound 3.”

Despite the paucity of peer-reviewed research studies on Hydrafinil in humans, there are many promising informal reports published by human research subjects on the new compound. Here is an account [4]:

“T:+1h – The effects are in full swing. This dose is reminiscent of the highest doses of Adrafinil I have tried, but subjectively it feels cleaner. The wakefulness promotion provided by Hydrafinil can only be described as clean stimulation (not in the same vein as standard stimulants).” [sic]

Put another way, Hydrafinil, like Modafinil, is not a stimulant in the traditional sense. Subjects on hydrafinil report gaining more focus and alertness without feeling "wired" or jittery, which can happen with other cognitive enhancers such as Adderall and caffeine.

Hydrafinil Potentially Reduces Daytime Fatigue

While Hydrafinil is not approved by the FDA for any use, much less treating fatigue, one anecdotal report suggests that Hydrafinil helps relieve fatigue within 30 minutes in subjects with busy lifestyles.4]:

“… T:+30m – I started to feel the effects of the initial dose beyond what I imagine a placebo to be. I am usually a little fatigued due to lack of sleep, due to my work schedule, this fatigue is almost completely gone.” [sic]

Daytime fatigue is a common problem that can make even the smallest decision seem like an arduous task. Hydrafinil reportedly eliminates that feeling, making it easier to make decisions throughout the day.

Hydrafinil potentially promotes wakefulness without altering the subject's sleep schedule

Although pharmacokinetic data for hydrafinil remain limited, the same anecdotal testimony suggests that the wake-enhancing effects of the investigated nootropic do not come at the cost of interfering with the subject's sleep schedule [4]:

“T+4.2h – The dosage loses effectiveness and there is a return to the initial value. There is no accident of any kind to write home about, but simply a return to basic vigil…” [sic]

This may be explained by the more potent but shorter duration of Hydrafinil. Subjects report that Hydrafinil causes a greater increase in cognition than Modafinil, but that it lasts only 4 to 6 hours, compared to Modafinil's 12+. Hydrafinil's shorter half-life means it is potentially much less likely to interfere with the sleep schedule of a human subject.

Hydrafinil can potentially be used for polyphasic sleep cycles

Anecdotes from research subjects on Reddit promote hydrafinil as a way to enter polyphasic sleep: the practice of sleeping for multiple periods throughout an entire day. Some biohackers use the polyphasic sleep pattern to complete more tasks. Hydrafinil has given at least one subject the boost in wakefulness they needed to adapt to this way of resting [5]:

“One person stayed awake for 40 hours taking hydrafinil taking it every four hours. At 35 hours, the person was still functioning normally and had Hydrafinil. At 36 hours, the effect of the hydrafinil wore off and the person became extremely sleepy and tired and began hallucinating due to extreme lack of sleep. Then the person took hydrafinil and it worked fine for the last four hours. The person even helped someone with homework and played video games as if he were rested. The person crashed 40 hours after the hydrafinil wore off and was sleeping for many hours.” [sic]

While the polyphasic sleep pattern may not be for everyone, this may indicate another possible research application of Hydrafinil.

Hydrafinil is potentially even less addictive and more effective than modafinil in promoting alertness

Like Modafinil, Hydrafinil is not a stimulant in the traditional sense. It is a weak dopamine transporter (DAT) agonist, meaning it can increase alertness with minimal risk of addiction.6]:

“Fluurenol belongs to a class of drugs known as eugeroics. These are stimulants that produce long-lasting mental excitement that leads to wakefulness. The idea behind the production of these drugs is to improve alertness without necessarily causing peripheral bodily effects or, better yet, abuse/tolerance/addiction of common stimulants.

And Fluorenol is no different. The stimulation of dopamine pathways by hydrafinil is much less substantial than that of modafinil, meaning it is less likely to be addictive.”

Overall, Hydrafinil appears to merit further investigation as an alternative to Adrafinil and Modafinil.This investigational compound has the potential to create a stronger cognitive boost than modafinil at a lower dose, without some of the side effects associated with the latter two.

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Hydrafinil Dosage, Side Effects, and Safety

Given the lack of scientific research on hydrafinil to date, you may be curious about its side effects or whether it is safe to use to improve cognition.

NOTE: We are not aware of any toxicology studies, human studies, or clinical reviews conducted with Hydrafinil to date. This means that researchers and their subjects are fully responsible for any effects that may arise from the responsible use of Hydrafinil.

From the testimonials we were able to gather, it appears that most subjects do not report any side effects when taking Hydrafinil in the range of 20 mg to 250 mg per day. Possible health effects reported by Acros Organics, a chemical supplier of Hydrafinil under the common name 9-hydroxyfluorene, include [7]:

• Eye irritation,
• skin irritation,
• Nausea,
• diarrhea and
• Vomiting

Importantly, Hydrafinil's material safety data sheets also indicate that the toxicology of this compound has not been fully investigated. Hydrafinil is not intended for human consumption and there is no peer-reviewed scientific data to support a safe dosage range. Anecdotally, the most common daily dose of Hydrafinil appears to be 25 to 50 mg.

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Hydrafinil Legality

Is it legal to buy and use Hydrafinil? To summarize: it certainly does not have the same legal status as modafinil.

In the United States, Modafinil is a Schedule IV prescription medication. That means you need a prescription to buy Modafinil at a pharmacy and you cannot share or sell it to anyone.

As we mentioned above, Hydrafinil is an analogue of Modafinil, so it is not subject to the same restrictions. However, for those of you wondering if the well-known Federal Analogues Act (21 U.S.C. § 813) applies to hydrafinil... no [8]:

“…[the law allows] any chemical substance “substantially similar” to a controlled substance listed in Annex I or II It should be treated as if it were included in Schedule I, but only if it is intended for human consumption. (emphasis ours)

In other words…

Hydrafinil is an uncontrolled and unregulated research chemical that is not approved by the FDA for human use.

For this reason, you may see online vendors advertising Hydrafinil with a disclaimer to the following effect:

“This material is sold for research purposes only. It is not intended for human consumption, medical uses, household uses or veterinary uses.”

Based on our personal experience and having collected data from hundreds of Hydrafinil research subjects, here is a short cheat sheet that tells you what all of the above means:

• Hydrafinil, like Modafinil, will not appear on a drug test unless specifically evaluated by the examiner [9].
• Researchers can buy Hydrafinil online in restricted quantities without a prescription, similar to how one could buy modafinil online as a nootropic.
• It is 100% illegal to sell Hydrafinil to others due to its status as a research chemical [10].

In summary, researchers are fully responsible for the proper use of Hydrafinil and any legal consequences that may arise from its purchase, possession and/or use.

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Pharmacology of hydrafinil

Researchers have speculated that Hydrafinil's primary mechanism of action is actually very different from Modafinil, Adrafinil, and related analogues.11]:

“Dunn [8,9] reported that fluorenol, which is the 9-hydroxyfluorene derivative formed from 9-fluorenyl-S(=O)-CH2-C(=O)-(4N-piperazine-1N)- C(=O) -CH3 itself shows a stronger eugeroic effect but a 59% weaker DAT binding capacity than modafinil. This result is unusual as fluorenol is very different structurally from modafinil, indicating a mechanism quite different from that of modafinil.

Since the fluorene moiety can readily accommodate electron binding, an investigation of electron binding to fluorenol showed no evidence of elongation of the fluorene C9-OH bond, ruling out the formation of a fluorene radical anion species similar to shown by 9-fluorenyl-S. (=O)-CH2-C(=O)-(4N-piperazine-1N)-C(=O)-CH3. However, an examination of electron binding to the protonated fluorenol species 9-fluoreneOH2+ showed an elongation of the fluorene-OH2+ bond, indicating a dissociative electron-binding reaction.” [sic]

Hydrafinil's main action does not come from binding to DAT and inhibiting dopamine uptake, so it is thought to be less addictive than other DAT agonists.

The dissociative electron bonding reaction is a way to absorb free radicals. The buildup of free radicals in the brain during the day is thought to be one of the many drivers of sleep.12]:

“This study demonstrates that examination of modafinil and modafinil-like analogs that have been shown in the literature to exhibit cognitive and wake-promoting psychobiological properties produce free radicals when subjected to electron binding. "Such observations are consistent with a cognitive impairment and eugeroic mechanism of free radical oxidative stress for modafinil and its related analogues."

In other words, the metabolism of modafinil and its analogues shows that, in addition to DAT binding, the presence of free radicals in the brain drives sleep and removal of these free radicals can reverse this action.

“A meta-analysis of published studies on sleep deprivation and oxidative stress in the brain was used to test the hypothesis that sleep is a dynamic resting state with antioxidant properties. Wakefulness is thought to involve high neuronal metabolism and potentials.” neuronal electrical, and requires high levels of oxygen and, therefore, oxidants.

Sleep is a state with increased antioxidant activity that promotes protection of the brain against free radicals by reducing the production of oxidants. “ROS (reactive oxygen species) and other markers of oxidative stress can accumulate in the brain during wakefulness and therefore behave as sleep promoters.”

These data, together with the observation of a dissociative binding mechanism in Hydrafinil, suggest that the eugeroic effect of Hydrafinil comes from its ability to absorb free radicals in the brain. This action is important as Hydrafinil is reported to be a more potent eugeroic without the side effects of many other eugeroics available as prescription medications or research chemicals.

Applying this data to practical use, many subjects report that Hydrafinil takes between 30 and 60 minutes before taking effect and lasts a total of 6 to 8 hours. For this reason, Hydrafinil is likely to have a shorter half-life compared to Half-life of modafinil 12-15 hours.

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Where to buy hydrafinil online | 2022

So where can you buy Hydrafinil online without having to worry about product quality or shipping issues?

After thoroughly reviewing the few suppliers that have Hydrafinil in stock, only one candidate met our strict requirements...

Science.bio is without a doubt our favorite place to buy high quality hydrafinil online.

Despite being a relatively new company, Science.bio (formerly IRC.bio) has managed to establish itself as a highly reliable supplier of premium research chemicals, such as Hydrafinil and many others.

Here's what you can expect when you order Hydrafinil at Science.bio.

Excellent client service

His communication with his clients is timely and professional. Having submitted several queries ourselves, we were impressed by how quick and helpful their responses were.

This is directly reflected on their TrustPilot page, where they have a rating of 4.5/5 out of 25 reviews at the time of writing. The review below is a good summary of what you can expect from this provider [13]:

“Highly recommended for reliable research products and fast, exceptionally helpful customer service... Since then, I have been satisfied with several orders each month.

Consistent quality with a wide variety of secure payment methods to work with. Many special offers and coupons may also be available for all types of customers throughout the year.”

Total transparency on product quality

According to their official website, all products offered by Science.bio are “rigorously verified by PhDs in analytical and organic chemistry, including NMR, FTIR, polarimetry, HPLC, and LC-MS analysis.”

Every nootropic they ship comes with a comprehensive data sheet, along with full audits of their production batches and product potency evaluated through an independent Certificate of Analysis (CoA).

Considering Hydrafinil's status as an investigational chemical, this information is mandatory for consumers.

FAST shipping times

All orders on Science.bio are shipped within 24 hours and a tracking number is immediately provided.

NOTE: Realistically, you should allow a time period of 1-3 days due to the current situation involving the COVID-19 pandemic.

We highly recommend stocking up on Hydrafinil and other products as FREE first class international shipping is offered to customers who place an order over $300.

Your order will come professionally packaged, so you never have to worry about the integrity of your research product.

And in case you do not receive your product, or if the product arrives defective, Science.bio offers a 30-day 100% money back guarantee.

Numerous payment methods

One of the main problems with online vendors is that there are very limited options for completing payment.

Fortunately, science.bio accepts several options to adapt to your clients and their needs:

• Credit card (Visa, MasterCard);
• electronic check;
• Bank transfers;
• Bank transfers; and
• Bitcoin (save 5% of your total order price)

Based on our conversations with research subjects, this list covers 99% of the most common payment methods.

All in all, Science.bio is the number one supplier of hydrafinil And we highly recommend them!

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Hydrafinil Review | Verdict

So what can be concluded from this exhaustive Hydrafinil Review?

Despite being a relatively new research chemical, there are already a significant number of researchers and subjects who claim that hydrafinil is an effective nootropic, comparable in some ways to modafinil.

Here's what we know so far:

Hydrafinil promises powerful cognition-enhancing effects and is potentially a must-have nootropic for short periods of incredible productivity and sharp focus. It is safe to take, easy to obtain, affordable and has few known side effects.

Research on Hydrafinil has indicated that it may be effective in improving cognition while at the same time being less likely to interfere with the subject's sleep schedule.

But not everyone will agree with the above statements and some subjects may not get the desired or expected result from taking Hydrafinil. Its potency, therefore, is completely individual to the subject and its unique biochemical composition.

Happy research!

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